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Increased levels of both oxidants and lipid peroxidation products, such as 8-isoprostane, have been detected consistently in the exhaled breath condensate of patients with COPD, along with significantly elevated levels of HNE and its adducts by at least 50% in the airway and alveolar epithelial cells, endothelial cells, and neutrophils of COPD patients [130,131]

What holds that single-cell layer together are tight junctions the protein seals between adjacent epithelial cells that determine how tightly the barrier is closed

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[DOI] [PMC free article] [PubMed] [Google Scholar] Dahl J, Ormstad H, Aass HC, Malt UF, Bendz LT, Sandvik L, Brundin L, Andreassen OA (2014) The plasma levels of various cytokines are increased during ongoing depression and are reduced to normal levels after recovery

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