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In addition, tumor-on-a-chip integrates tumor and stromal cells instead of healthy tissue cells, to mimic invasive tumor behaviour and TME dynamics (Li et al., 2023a

However, these mutations can be a risk factor for folate deficiency, which may lead to various health issues if left untreated

Constitutive overexpression of the proto-oncogenes c-myb in Balb/c-3T3 cells increases expression of both IGF-1 and IGF-1R, at least partly through an increased transcriptional activity and in this way abrogates the requirement for IGF-1 in the growing media (Kim et al, 1996)

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