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Depletion of holoTC by folic acid in individuals with already low vitamin B-12 status further compromises the availability of vitamin B-12 coenzymes to their respective enzymes, and consequently a more pronounced state of biochemical deficiency

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Site rotation importance Repeatedly injecting in the same location can cause local tissue changes including lipohypertrophy (abnormal fat accumulation) or lipoatrophy (fat loss creating depressions)

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