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Calcium overload within the sarcoplasmic reticulum (SR) can trigger spontaneous diastolic Ca 2+ releases through ryanodine receptors (RyR2), generating delayed afterdepolarizations (DADs) and potentially causing arrhythmias [53]

These soluble factors play a crucial role in recruiting and activating additional immune cells to the infection site, thereby enhancing the clearance of pathogenic fungi

Nitazoxanide: a first-in-class broad-spectrum antiviral agent

By deconstructing herbal formulas into their constituent compounds and targets, this approach provides mechanistic insights into how multi-component therapies achieve synergistic efficacy

10.1038/jcbfm.2011.149 85 PierohP.BirkenmeierG.DehghaniF

doi: 10.1038/s41398-021-01583-5 130 ZhangSZhouNLiuRRaoWYangMCaoBet al
