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Another study in mice also showed that dietary butyrate supplementation prevented and reversed high-fat-dietinduced obesity by downregulating the expression and activity of PPAR-, promoting a change from lipogenesis to lipid oxidation (88)

FIGURE 8 The aforementioned abnormalities at the molecular level (downregulation of the Nrf2/HO-1 axis and GPX4) and subcellular structural level (neuronal somata and mitochondrial impairment) were consistent with the GSH metabolism perturbations identified by multi-omics analyses, collectively reflecting oxidative stress-associated damage in the hippocampus during SAE

Despite expressing similar markers, TAMs may not always have similar functional implications

Physiol Rev 90: 1383-1435

Scientists narrowed the dataset to a targeted group of seven genes by combining the 189 mRNAs linked to the chosen miRNAs with the 640 mRNAs previously found to be related to embryo quality