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Phase I is purely post-synaptic with constant twitch depression, whereas Phase II reflects combined mechanisms with characteristic fade on repetitive stimulation

These characteristics make it an ideal model cultivar for detecting improvements in yield, biochemical traits, and stress adaptability induced by treatment, under controlled conditions

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Some similar conditions are also there, which develop vitamin B12 deficiency in persons, such as Crohns disease or celiac disease

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However, studies in animals and humans have revealed that Gd 3+ (free or chelated) is retained in a number of tissues in those without renal impairment