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The temperature difference between refrigerated solution and body tissue creates a localized reaction that manifests as stinging or burning

Individuals who have had gastric bypass surgery are also at risk due to alterations to the GI tract that impair the release and absorption of B12

A total of 22 studies (3 in vitro, 8 animal, 11 human observational studies) were included

Applying a cold compress and avoiding rubbing the area can provide relief