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7b), confirming our hypothesis

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Co-ingestion of kava with prescription medications or over-the-counter products, including other herbal remedies that are metabolized with one or more of these enzymes, might result in elevated and potentially toxic concentrations of the co-administered agents or their metabolites (81)

In clinical high-risk for psychosis (CHR) samples [12,13,14], cannabis use is associated with worsened subthreshold symptoms, and among those with established schizophrenia, it may exacerbate symptom severity and increase relapse risk [15,16,17]