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What is the difference between resistant hypertension and refractory hypertension

The first is dependent on the folate coenzyme 5-methyltetrahydrofolate that can donate a methyl group to homocysteine in a reaction catalyzed by the vitamin B 12 dependent enzyme methionine synthase

Giusti F, Casiraghi M, Point E, Damian M, Rieger J, Bon CL, et al

This finding is in agreement with observations made by previous workers (Shviro and Shaklai 1987

Thus, the enzymatic activity of HMGCS2 is regulated through post-translational modifications under both physiological and pathological conditions

Experiments were performed in strict accordance with the National Institutes of Health (NIH) Guidelines for the Care and Use of Laboratory Animals
