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Apoptotic markers such as caspase 3 (Cas-3), B-cell leukemia/lymphoma 2 protein (BCL-2), BCL-2-associated X protein (BAX), and cytochrome C (Cyt-C), together with endoplasmic reticulum stress markers including C/EBP homologous protein (CHOP), glucose-regulated protein 78 (GRP78), and caspase 12 (Cas-12), contribute to alveolar epithelial and endothelial damage

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Nature 460 , 392395 (2009)

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Recovery is usually gradual, but a consistent effort can lead to significant improvement