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Research has shown these genes can be turned on via cell-signaling pathwaysthe major one being Nrf2
Immunology 115:108117 Chatterjee S, Basak AJ, Nair AV, Duraivelan K, Samanta D (2021) Immunoglobulin-fold containing bacterial adhesins: molecular and structural perspectives in host tissue colonization and infection
Despite their antitumor efficacy, glycolysis inhibitors lack selectivity because of the role of glycolysis in normal cells
However, under oxidative stress or pathological conditions like AGEs (72), Nrf2 is activated and translocated to the nucleus, initiating the expression of antioxidant genes such as GPX4, which are essential for reducing lipid peroxidation and delaying ferroptosis (73)
J Glaucoma
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