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The polarization of M1 macrophages is generally triggered by the synergistic action of inflammatory cytokines, such as IFN- and TNF, along with Toll-like receptors (TLRs) [94]

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Circadian timekeeping in anticancer therapeutics: an emerging vista of chronopharmacology research

Experiments are conducted using various animal disease models and applied to compound screening to achieve relatively high-throughput screening (HTS) [123]

Similar to non-melanoma skin cancer, the invasion of melanoma cells can be facilitated by the action of MMPs, which modify basement membrane and ECM proteins (203)