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In specific relation to the immune system, glutathione deficiency is known to impair immune function

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Therefore, ferroptosis can significantly affect DED development

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Hyperglycemia drives the accumulation of advanced glycation end products AGEs, which activate the RAGE/MAPK signaling axis, thereby inhibiting Col-II synthesis and promoting a catabolic state in chondrocytes (31)

Neutrophil extracellular traps (NETs) NADPH oxidase-derived oxidants are thought to mediate activation of other neutrophil killing strategies against pathogens