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Oral vs Intravenous Indeed, after several searches in scientific literature, only a single case report was found describing a possible link between oral methylene blue and serotonin syndrome 27
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27 However, patients are encouraged to weight-bear when possible and are educated about re-presentation in the setting of calf pain, shortness of breath or chest pain

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Additionally, Flux Sum Analysis 39 is used to obtain the metabolite pool size in different conditions (M1 and M2)