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Extracellular vesicles in the central nervous system: a novel mechanism of neuronal cell communication

Recent preclinical and clinical data support the promise of several agents

While higher contamination levels yield results in as little as 6 hours, lower concentrations and cooler temperatures may take up to 24-48 hours

Analysis of donor islets in the Human Pancreas Analysis Program (HPAP) has revealed altered expression of genes involved in insulin granule docking and exocytosis in donors with IGT and type 2 diabetes, including reduced expression of STX1A , VAMP2 and UNC13A , which are critical components of the vesicle fusion machinery [23]