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Vitamin C and glutathione Free radicals are all around us every day in the form of environmental pollution, toxic chemicals, and cigarette smoke

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Induction and measurement of murine pulmonary fibrosis Pulmonary fibrosis was induced in female C57BL/6 mice (1012 weeks old) by a single intratracheal instillation of 50 l of bleomycin (3 U/kg, Sigma Aldrich, Taufkirchen, Germany) dissolved in sterile saline, and applied using the MicroSprayer Aerosolizer, Model IA-1 C (Penn-Century, Wyndmoor, PA)

The GRADE assessment showed moderate certainty of evidence for the increase in serum vitamin B12 levels and low certainty of evidence for homocysteine reduction, both across all studies and within RCT-only and observational-only subgroups

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BMJ open 10 (8), e033687