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In the gut, glutathione is essential for maintaining the redox balance and protecting against oxidative stress-induced damage (208)

Holzinger, B., & Mayer, L

Cumulatively, these data indicate that treatments aimed at increasing GSH levels in the brain may be a viable option for treatment and prevention of neurodegenerative disease

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There is a large degree of biological plausibility as many of these phenomenons are widly accepted and are logically presented in regards to the sequence of key events

At light of all considerations mentioned in the former paragraph, regarding the few longitudinal studies, and also that the epigenetic modifications observed in a certain window of time may be transitory, we think that, with the results obtained in the 116 papers reviewed, we cannot give an insight about the possible consequences of such DNA alterations, since this would be speculative