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The ZIP1 protein is responsible for the active transport of Zn into prostate cells, and its expression has been reported to be significantly reduced in prostate cancer (Costello et al., 2016[98])

Together, they tackle both surface lines and deeper structural aging

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In molecular docking models, it has been observed that curcumin fits into the active site of histone deacetylase HDAC8, forming contacts with residues Arg37, Pro35, Ile34, and Phe152 of the catalytic pocket

[2] [32] Administering of the first non-clinical doses The first dose administered outside of a clinical trial was given to 90-year-old Margaret Keenan in the outpatient ward at Coventry University Hospital on 8 December 2020