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Cholesterol and polyunsaturated fatty acids potential risk factors in glaucoma also modulate TRPV4 activation (135)

Taken together, the action mechanisms of AFB1-exposure-induced mitochondrial dysfunction may include direct damage to the mitochondrial ultrastructure, a decrease in mitochondrial membrane potential, inhibition of TCA cycle-rate-limiting enzymes and mitochondrial biogenesis, loss of ETC complex activities, and a decrease in ATP levels

3, 4, 5 However, it is the paracellular pathway, regulated by the tight junction (TJ), that is responsible for the greatest degree of apical cellcell adhesion, 6, 7 and which has received the most attention for its role in regulating mucosal permeability under normal and pathological conditions

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doi: 10.1016/j.isci.2022.103827 183 SivandzadeFPrasadSBhaleraoACuculloL

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