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39, 40 The consequence of an overall increase in ROS is a reduction in the bioavailability of NO

The animal research, while promising, doesn't translate directly to human use, and the FDA has determined that insufficient safety data exists for compounding

[DOI] [PubMed] [Google Scholar] 309.Diabetes C., Complications Trial Research G., Nathan D.M., Genuth S., Lachin J., Cleary P., Crofford O., Davis M., Rand L., Siebert C

With NNMT blocked, nicotinamide stays in the cell, NAD+ levels climb, and fat cells start burning more fuel instead of storing it

tGSH levels were (a) significantly decreased in young relative to old adults (Nuttall et al., 1998), (b) significantly decreased in young adults (2735 yrs) compared to young to middle-aged (3657 yrs) (Kretzschmar et al., 1991), while (c) no significant differences were observed between middle-aged to old (5570 yrs) and old (7085 yrs) adults (Andriollo-Sanchez et al., 2005)

The documented research protocol is once-daily dosing in the activation phase (roughly weeks 1-4), then the same per-dose amount at a reduced 3-5x/week frequency in maintenance