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Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex i

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TMAO (Trimethylamine-N-oxide): A metabolite linked to cardiovascular risk at high levels

RNA concentration and purity were determined with a NanoPhotometer (Implen GmbH, Munich, Germany) and it was stored at 80 C until further use

Existing polyphenol interventions show that daily intake (over 4 to 8 weeks) of berry-, grape-, or apple-derived products can modestly lower fasting TMAO (3639), yet none of these has examined how polyphenol-rich interventions influence full 48-h post-OCC plasma TMAO profiles from precursors such as L-carnitine

Oct 2010;18(5):357-62