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804 Lipid peroxide 4-HNE, which accumulates during myocardial I/R injury, promotes ubiquitination of GPX4 and induces cardiac ferroptosis by targeting the binding site of GPX4 and ovarian tumor deubiquitinase 5, while activation of aldehyde dehydrogenase 2 to degrade 4-HNE reduces myocardial ferroptosis
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Yet, natural glutathione levels decline with age, inflammation, and chronic stress
doi: 10.1046/j.1471-4159.1998.71052112.x
Similarly, Natural compounds such as oleanolic acid (OA) and ursolic acid (UA) can inhibit the growth of BPH cells by inducing autophagy and reducing the expression of the IL-8 axis [107]
Regulation of energy metabolism in human cells in aging and diabetes: FoF(1), mtDNA, UCP, and ROS
