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Cognitive and Mood Disturbances : Vitamin B12 plays a role in brain health, so deficiency can lead to memory problems, difficulty concentrating, depression or irritability

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Monitoring focuses on glucose handling, IGF-axis context, cardiovascular risk, and symptoms that may suggest excessive pathway activity

These exposures may cause localized inflammation and the release of reactive oxygen species (ROS) within colorectal tissues, which may be causative or promotive of neoplastic processes