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Of note, XKR8 KO neutrophils failed to form NETs in response to various stimuli in vitro, including PMA, calcium ionophore A23187, lipopolysaccharides (LPS), nigericin, monosodium urate (MSU) crystals and zymosan

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2008 Jun;4(2):89-96

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MDHA is either directly reduced back to AsA by MDHAR or undergoes non-enzymatic disproportionation to AsA and dehydroascorbate (DHA)

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