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298 Notably, mitochondrial copper can directly bind to proteins following their lipoylation, a post-translational modification involving the covalent attachment of an eight-carbon organosulfur lipoic acid moiety to specific lysine residues, leading to the aggregation of lipoylated proteins

Discontinuation may be warranted if allergic reactions occur, if side effects persist despite slower dosing, or if baseline conditions (acute kidney injury, active infection) change

Implications for Crohns disease

10.1016/j.ejphar.2013.05.029 60 SantiniS

257, L163L173

In a pre- and postnatal development study of SNAC exposure, an increase in gestation length, an increase in the number of stillbirths, and a decrease in pup viability were observed