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Most are mild and temporary
Pharmacologic GLP-1 receptor activation improves glucose homeostasis through glucose-dependent insulin secretion, suppression of inappropriate glucagon secretion, delayed gastric emptying, and reduced appetite
Many people start with semaglutide and switch to tirzepatide if needed, which is a reasonable strategy

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A one-way ANOVA revealed an almost significant main effect of NNMT inhibitor treatment on intracellular NAD + levels (F (5,6) = 4.131, P = 0.0568) (Figure 3B)