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Nakamura 2007)

Users report steady improvements over months rather than dramatic short-term changes, which often indicates sustainable rather than inflammatory response

Estrogen dominance may contribute to altered immunity, which may then contributes to development and/or progression of endometriosis

If you start HRT during perimenopause, your periods may: Continue as normal Become lighter Become heavier Occur more or less frequently Become more predictable HRT does not typically stop periods immediately during perimenopause because your ovaries may still be producing hormones

However, the frequent occurrence of compensated activation of alternative pathways prominently hinders the efficacy of targeting one single metabolic paradigm

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