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Dexmedetomidine (DEX), an 2-adrenergic receptor, also augments the expression of SLC7A11

Another study also showed that 5 mM NAC only slightly mitigated the loss of activity in three cell lines, NCIH2030, A549, and HCC4009, in response to elesclomol (13)

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The cells were incubated overnight at 4 C with one of the following primary antibodies: rabbit anti-SMAD2 (Cell Signaling Technology, Danvers, MA, RRID: AB_823638, 1:200 dilution), rabbit anti-SMAD3 (Cell Signaling Technology, RRID: AB_2193182, 1:200 dilution), rabbit anti-phospho-SMAD2 (Abcam, RRID: AB_2732791, 1:100 dilution), or rabbit anti-phospho-SMAD3 (Cell Signaling Technology, RRID: AB_2193207, 1:100 dilution)

Its main function is to transport intracellular glutamate out of the cell while concurrently bringing extracellular cystine into the cell, serving as one of the primary sources of intracellular cysteine