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Other investigators have attempted to facilitate the availability of central brain-derived neurotrophic factor (BDNF) with injections of human BDNF directly into the patients brain with minimal positive results [17]

doi: 10.1016/j.imbio.2020.151999

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Assay performance and Validation of NADMED Assay Against Mass-Spectrometry NADMED assays demonstrated high precision with intra-assay coefficients of variation (CV%) ranging from 2.28 to 9.02, and inter-assay precision from 3.93 to 9.37

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26 Consistent with this, -synuclein overexpression in worm dopaminergic neurons using the dat-1 promoter (P dat-1 ) induces neurodegeneration in the six anterior dopaminergic neurons (Supplementary Figure S1a)