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These mechanisms suggest that ferroptosis could serve as a pivotal trigger point for initiating the positive feedback loop involving CD8 + T cell-mediated eradication of tumor cells, thus significantly enhancing antitumor activity

Thus, glutathione depletion triggers death consistent with ferroptosis in BT-549 cells and identifies lipid hydroperoxides as the lethal ROS species underlying glutathione addiction in these cells

Adjustment Criteria: Decisions on treatment changes depend on the initial deficiency level, neurological symptoms, and how well the patient responds

For instance, resveratrol pretreatment potently reduces hippocampal neuron death in kainic acid (KA)-induced epileptic seizures (Wang et al., 2004)

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Alireza Ahmadvand and Maryam Baeeri for participating in this research