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Cytokines and the acute phase response to influenza virus in mice

By performing an unbiased scRNAseq analysis of tumors in mice with conditional deletion of EGFR in myeloid cells, we demonstrate an altered immune cell infiltration and a less immunosuppressive TME, accompanied by reduced activation of inflammatory signaling pathways in myeloid cells, impacting their communication with T cells

While obesity initially triggers increased autophagy as an adaptive response, chronic metabolic stress leads to autophagy dysfunction

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Cox SE, Ellins EA, Marealle AI, et al

10.24072/pcjournal.394 18 ChenQ.AllgeierA.YinD.HollertH