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Gastrointestinal symptoms often present years before motor symptoms in PD and evidence suggests gut microbes play a role in PD pathogenesis via the microbiota-gut-brain axis (52)

found that modulating the PKC/NRF2/Bcl-2 signaling pathway can enhance the clinical efficacy of sitagliptin, improving diabetes-induced testicular dysfunction [47]

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Yang Y, Fan S

N-acetylcysteine reverses cocaine-induced metaplasticity

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