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Data availability Transcriptomic data used in this study are available from GSE104954, GSE142025, GSE220939, GSE99340 and GSE183279

"Association between weight or body mass index and hand osteoarthritis: a systematic review"

Caspase-6 acts as a scaffold to amplify ZBP1-dependent inflammasome activation and participates in PANoptosis (coordinated activation of pyroptosis, necroptosis, and apoptosis), thereby regulating macrophage polarization and the immune microenvironment

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In fact, 64% of plastic surgeons report seeing a rise in cosmetic surgery or injectable treatments for patients in their early 30s