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Drosophila lacking SOD1 have a dramatically shortened lifespan, whereas flies lacking SOD2 die before birth

Excessive intracellular free radicals inhibit the activation of protein kinase Avia (PKA) oxidative modification of thiol groups in cysteine residues, while a large amount of ROS released during mitochondrial oxidative stress could further exacerbate this inhibition [20], IDB protected PKA from oxidative damage by suppressing the generation and accumulation of mitochondrial ROS [36]

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159 The crystal structure of human GPI has been resolved

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The catalytic mechanism employed by GPX4 adheres to a ping-pong mechanism, characterized by the dynamic interchange of the enzyme's active site between oxidation and reduction states (Fig