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For example, MMP-9, produced by both AECs and Thy-1-negative fibroblasts, not only activates TGF- to sustain a profibrotic cycle but also enhances fibroblast migration and collagen deposition (Kobayashi et al., 2014), thereby contributing to abnormal alveolar bronchiolization

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However, based on the large degree of renal metabolism of pramlintide, hepatic dysfunction is not expected to affect exposure

It has also been shown that aldo-keto reductase family 1 member B1 (AKR1B1) interacts with signal transducer and activator of transcription 3 (STAT3) to up-regulate SLC7A11, which leads to increased Cys 2 uptake in lung cancer cell lines and xenograft mouse models, and further promotes lung cancer cell resistance [80]

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-F][triazin-4-Amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

Cheng CY, Yen MY, Chen SJ, Kao SC, Hsu WM, Liu JH
