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However, compounds with an amino acid-based structure (i.e., peptides, proteins, peptidomimetics), including those used in therapeutic applications, have a number of serious limitations, such as conformational instability, short duration of action (short half-life), and insufficient penetration through the bloodbrain barrier (BBB) [3,4,5]

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NAD + is concentrated in the mitochondria, with lower concentrations in the nucleus and cytoplasm 76,77