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This underdiagnosis can lead, besides death in 20% when it is not appropriately treated, to Korsakoffs syndrome, a severe dysfunction often following untreated Wernickes encephalopathy, that does not remit even with thiamine treatment and is associated with chronic alcohol abuse and chronic thiamine deficiency (, , , )

Superoxide undergoes rapid spontaneous conversion into H 2 O 2 , or catalysis by superoxide dismutase (SOD) to form H 2 O 2

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