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Although these HLA associations have contributed to our understanding of the immunopathogenesis of DILI, the very poor positive predictive value of the HLA allele for development of DILI means that other factors must be involved, and the associations will not translate into a viable screening strategy to prevent the development of disease

Gastroenterology 56 (8), 920928

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These receptors increase the antigen-presenting capacity of Langerhans cells hundreds or even thousands of times

Numerous studies have shown that the WNT/-catenin pathway and PPAR act in an opposite manner, including psychiatric disorders, neurodegenerative diseases, and fibrosis processes [80,148,149,150,151,152,153] (Figure 3)

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