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A separate meta-analysis confirmed that caffeine and catechins together significantly increase both energy expenditure and fat oxidation beyond placebo (Hursel et al., 2011)
Histological and biochemical similarities have been found on muscle biopsies from patients with mitochondrial encephalomyopathy or with migraine [22,23]
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Or look at Tesofensine, which works centrally in the brain by inhibiting the reuptake of neurotransmitters like dopamine, serotonin, and noradrenaline, thereby influencing appetite and energy expenditure
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