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On the other side of the spectrum, the only FDA-approved glutamine therapy is in sickle cell disease (SCD) patients of all ages based on a Phase III clinical trial where L-glutamine was well tolerated and reduced pain crisis [96]

As a result, there is an accumulation of TCA cycle intermediates (e.g

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doi: 10.1002/mds.26069 54

23 Other pathways for Cu elimination such as urine, sweat, and menses play a relatively minor role in Cu loss

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