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further conducted transcriptome study of db/db mice treated with angiotensin receptor blocker (ARB) and sodium-glucose cotransporter two inhibitors (SGLT2i), and indicated that ARB provided more anti-inflammatory and anti-fibrotic effects, whereas SGLT2 affected mitochondrial function in proximal tubules [12]

As a result, these approaches remain confined to the preclinical proof-of-concept stage

Science 353(6301):aad8670

Due to the highly specific selection and the resulting purity of target proteins, affinity-based systems have become the flagship method of purification