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The insulin concentration level decreased to approximately 0.4 ng/mL at 30 min after glucose administration and remained unchanged until 120 min afterward

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Osteoporos Int 22:26672675

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Indeed, silencing -syn has led to neuroprotection in vitro upon 1-methyl-4-phenylpyridinium (MPP+) insult (Fountaine and Wade-Martins, via a lentiviral vector silenced human -syn expression in rat striatum, and siRNA directed against -syn reduced the expression of endogenous -syn after 2 weeks of infusion into the mouse hippocampus (Sapru et al., In addition to targeting -syn mRNA translation processes, an alternative approach to reduce -syn protein expression seeks to interfere with the transcription of the -syn gene

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Prior to 2019, no studies adequately addressed these limitations

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