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BPI injuries are usually closer to the neck or under the collarbone, but it is the shoulder, elbow, arm, and hand that lose function

With iron-chelating properties and monoamine oxidase inhibitory activity, VK-28 derivatives (including M30, M32, and HLA20) target multiple neurodegenerative pathwaysthey suppress oxidative stress-related pathways (e.g., Keap1-Nrf2), modulate the AKT/mTOR pathway, and alleviate -syn aggregation (230)

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131 , e160657 (2021)

These secondary diagnoses can significantly impact MS-DRG assignment and risk adjustment

Altogether, these events result in neurodegeneration causing cerebral dysfunction, brain atrophy, and dementia [20,144,146], and emphasize that biochemical decompensation resulting from VitB12 insufficiency is not the sole contributor to demyelination