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ROS and toxic metabolites generated by ROSmediated cell damage give rise to oxidative stress that is apparently adverse to cell survival and further contribute to the induction of tumorigenesis.47 The Nrf2mediated antioxidant response is one of the major cellular defense mechanisms that protect against oxidative stress
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Acknowledgements This work was supported by a joint PhD studentship by the Norwich Medical School, University of East Anglia and by the Biotechnology and Biological Sciences Research Council Institute of Food Research, Norwich, UK
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