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Treatment Iron chelation treatment Despite the novel comprehension of the pathophysiology of -thalassemia, iron chelation therapy still remains the most efficacious approach for reducing the morbidity and mortality associated with iron overload in patients with NTDT and TDT (118)

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Accordingly, the release of spermatozoa through more frequent ejaculations might be a potential strategy to attenuate the detrimental effects of ROS and improve perm quality (Figure 2) (115, 118)

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