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Neoadjuvant chemotherapy is associated with increased expression of DNA repair proteins and epithelial to mesenchymal transition (EMT) in patients with non-small cell lung cancer (NSCLC)

In the group treated with NAC (42 patients out of 82), compared to the group without NAC, a statistically significant reduction was observed in the development of ARDS, the need for mechanical ventilation, and mortality

this associated in some studies with a subsequent homeostatic increase in endogenous inhibitors, including IL-1 receptor antagonist and TNF receptors 203,218,219,220

The final step of valine catabolism involves the conversion of methylmalonate semialdehyde to propionyl-CoA by the enzyme commonly identified as methylmalonate semialdehyde dehydrogenase, MMSDH
A., Parncutt, J
