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1 The cycle of depletion
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doi: 10.2174/138161212803582469

Going 5 days one week and 10 days the next creates fluctuating blood levels that can worsen side effects and reduce effectiveness

(1989) Fasting plasma homocysteine as a sensitive parameter of antifolate effect: a study of psoriasis patients receiving low-dose methotrexate treatment

If you have questions regarding vitamin dosing, its best to consult a medical professional
