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Upon binding, these complexes activate Gs-coupled intracellular signalling cascades, leading to adenylyl cyclase stimulation, elevated cyclic AMP (cAMP) production, and downstream activation of protein kinase A (PKA)

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Department of Health and Human Services

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Safety and efficacy of subcutaneous ianalumab (VAY736) in patients with primary Sjogrens syndrome: a randomised, double-blind, placebo-controlled, phase 2b dose-finding trial

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