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Endocrinologa y Nutricin (English Edition) 59(8):487490 Reinstatler L et al (2012) Association of biochemical B 12 deficiency with metformin therapy and vitamin B 12 supplements: the National Health and Nutrition Examination Survey, 19992006

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In clients without HLA-matched donors, the treatment of choice is immunosuppression of granulocyte-macrophage-colony-stimulating factors, cyclophosphamide, anti-thymocyte globulin, and cyclosporine