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Description
The reason is that LPS causes an immune response

Malik A, Eggersdorfer M, Trilok-Kumar G

Garca-Caballero M, Zecchin A, Souffreau J, Truong ACK, Teuwen LA, Vermaelen W, et al

Further experiments to characterise these changes are ongoing It was not possible to find a structural explanation for these dissolution changes with the used methods

Whittem T

It occurs when there are too many free radicals in the body